Therapy: What should we do after the failure of a first anti-TNF?

 Therapy: What should we do after the failure of a first anti-TNF?Chris DeightonNat Rev Rheumatol 5 (11), 596-7 (Nov 2009)info:doi/10.1038/nrrheum.2009.212Posted by persey to anti-TNF failure biological therapy rheumatoid arthritis on Thu Dec 03 2009 at 15:55 UTC | info | related

A pilot risk model for the prediction of rapid radiographic progression in rheumatoid arthritis

 A airman risk help for the prediction of fast radiographic progression in rheumatoid arthritisNathan Vastesaeger et al.Rheumatology 48 (9), (01 Sep 2009)info:pmid/19589891 | info:doi/10.1093/rheumatology/kep155Posted by persey to early arthritis anti-TNF therapy rheumatoid arthritis on Thu Nov 26 2009 at 14:01 UTC | info | related

Validation of a prediction rule for development of rheumatoid arthritis in patients with early undifferentiated arthritis.

 Validation of a prediction conception for development of rheumatoid arthritis in patients with early dedifferentiated arthritis.B Kuriya et al.Annals of the rheumatic diseases 68 (9), 1482-5 (Sep 2009)info:pmid/19015211 | info:doi/10.1136/ard.2008.092676Posted by persey to rheumatoid arthritis diagnosis early arthritis rheumatoid arthritis on Mon Oct 26 2009 at 22:35 UTC | info | related

Rheumatoid arthritis test

There is no single test for rheumatoid arthritis. Sometimes rheumatoid arthritis can cause bumps called nodules to form over the elbows, knuckles, spine, and lower leg bones. See a picture of the most commonly affected joints. The disease usually affects both sides of the body at the same time. The disease also runs in some families. This means that the body's natural defense system attacks the joints.

But rheumatoid arthritis is an autoimmune disease. The exact cause of rheumatoid arthritis is not known. Rheumatoid arthritis is 2 to 3 times more common in women than in men. Over time, this inflammation may destroy the joint tissues. Rheumatoid arthritis causes tissues lining the joints to become swollen, stiff, and painful.

Rheumatoid arthritis

Many of the medicines used to treat rheumatoid arthritis have side effects. Early treatment also may lower the chances that inflammation will destroy your joints and limit your daily activities. Experts recommend early treatment with medicines that may control rheumatoid arthritis or keep it from getting worse. Treatment includes medicine, exercise, and lifestyle changes. Treatment continues throughout your life. There is no cure for rheumatoid arthritis, but treatment may help relieve symptoms and control the disease.

A spontaneous rheumatoid arthritis-like disease in MRL/l mice.

A unprompted rheumatoid arthritis-like disease in MRL/l mice.L Hang, A N Theofilopoulos, and F J DixonThe Journal of empiric medicine 155 (6), 1690-1701 (01 Jun 1982)info:pmid/7077223Posted by jackhutcheson to rheumatoid arthritis RA on Fri Oct 02 2009 at 21:27 UTC | info | related

Causes of death in patients with rheumatoid arthritis from 1971 to 1991 with special reference to autopsy.

 Causes of modification in patients with rheumatoid arthritis from 1971 to 1991 with primary reference to autopsy.Riitta Koivuniemi, Leena Paimela, and Marjatta Leirisalo-RepoClinical rheumatology, (17 Sep 2009)info:pmid/19760078 | info:doi/10.1007/s10067-009-1278-9Posted by Terkko to rheumatoid arthritis on Wed Sep 23 2009 at 10:46 UTC | info | related

Rheumatoid Arthritis Info

Basically, TNF-alpha acts like a messenger that summons the immune cells of inflammation to participate in the inflammation. By blocking the action of TNF-alpha, Remicade reduces the inflammation and its accompanying signs and symptoms. Remicade does not cure rheumatoid arthritis. However, studies have demonstrated that Remicade can inhibit the progress of joint destruction from rheumatoid arthritis. Remicade can either be used alone or is often combined with methotrexate for treating rheumatoid arthritis in patients who have not adequately responded to methotrexate alone. In these patients, the drug is used to prevent joint damage that is caused by the rheumatoid arthritis.

Rheumatoid arthritis is a chronic joint disease that damages the joints of the body. The damage is caused by inflammation of the joint lining tissue. Inflammation is normally a response by the body's immune system to "assaults" such as infections, wounds, and foreign objects. In rheumatoid arthritis, the inflammation is misdirected to attack the joints. Rheumatoid arthritis is often referred to as RA. The inflammation in the joints causes pain, stiffness, and swelling, as well as many other symptoms. The inflammation often affects other organs and systems of the body.

Rheumatoid Arthritis Info

Rheumatoid arthritis in adults is characterized by three distinct stages. In cases in which JRA is suspected, an official diagnosis should be made by a pediatric rheumatologist. Other symptoms include joint stiffness following rest or decreased activity level , and weakness in muscles and other soft tissues around the involved joints. The most common features of JRA are: joint inflammation, joint contracture , joint damage and/or alteration or change in growth. Arthritis is best described by the four major changes in the joints that may develop. JRA can produce serious complications in more severe cases. Indeed, juvenile rheumatoid arthritis is the most common form of arthritis in children. The time of onset most typically strikes between the ages of 25 and 50, but in rare circumstances the disease has also been known to occur in children and senior citizens. It has been found that approximately half of all people with RA will experience a remission within 2 years of the initial onset of symptoms.